Clinical Papers

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Stifle and CCL

In vivoassessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study. Bone Joint J. 2019 Oct;101-B(10):1238-1247. doi: 10.1302/0301-620X.101B10.BJJ-2018-1282.R2. PMID: 31564153.
Smith PA, Bozynski CC, Kuroki K, Henrich SM, Wijdicks CA, Cook JL. Intra-Articular Biocompatibility of Multistranded, Long-Chain Polyethylene Suture Tape in a Canine ACL Model. J Knee Surg. 2019 Jun;32(6):525-531. doi: 10.1055/s-0038-1655765. Epub 2018 May 31. PMID: 29852514.  


Clinical paper references

Wright, B., Kronen, P.W., Lascelles, D., Monteiro, B., Murrell, J.C., Robertson, S., Steagall, P.V.M. and Yamashita, K. (2020), Ice therapy: cool, current and complicated. J Small Anim Pract, 61: 267-271.

WI Baltzer (2020) Rehabilitation of companion animals following orthopaedic surgery, New Zealand Veterinary Journal, 68:3, 157-167, DOI: 10.1080/00480169.2020.1722271

Janas K, Millis D, Levine D, Keck M. Effects of Cryotherapy on Temperature Change in Caudal Thigh Muscles of Dogs. Vet Comp Orthop Traumatol. 2021 Jul;34(4):241-247. doi: 10.1055/s-0041-1723786. Epub 2021 Feb 25. PMID: 33634436.

Szabo SD, Levine D, Marcellin-Little DJ, Sidaway BK, Hofmeister E, Urtuzuastegui E. Cryotherapy Improves Limb Use But Delays Normothermia Early After Stifle Joint Surgery in Dogs. Front Vet Sci. 2020 Jul 3;7:381. doi: 1c0.3389/fvets.2020.00381. PMID: 32719817; PMCID: PMC7350525.

Luethy D. Cryotherapy Techniques: Best Protocols to Support the Foot in Health and Disease. Vet Clin North Am Equine Pract. 2021 Dec;37(3):685-693. doi: 10.1016/j.cveq.2021.07.005. PMID: 34782099.

Quam V, Yardley J, Quam M, Paz C, Belknap J. Cryotherapy provides transient analgesia in an induced lameness model in horses. Can Vet J. 2021 Aug;62(8):834-838. PMID: 34341594; PMCID: PMC8281941.

Morgan J, Stefanovski D, Lenfest M, Chatterjee S, Orsini J. Novel dry cryotherapy system for cooling the equine digit. Vet Rec Open. 2018 Jan 7;5(1):e000244. doi: 10.1136/vetreco-2017-000244. PMID: 29344364; PMCID: PMC5761284.

Van Eps AW. Therapeutic hypothermia (cryotherapy) to prevent and treat acute laminitis. Vet Clin North Am Equine Pract. 2010 Apr;26(1):125-33. doi: 10.1016/j.cveq.2010.01.002. PMID: 20381741.

Orsini JA. The Big Picture in Better Understanding the Equine Foot. Vet Clin North Am Equine Pract. 2021 Dec;37(3):521-528. doi: 10.1016/j.cveq.2021.07.001. Epub 2021 Oct 19. PMID: 34674909.

Jacobs, CC,  O’Neil, E,  Prange, T.  Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpusVeterinary Surgery.  202251(7): 10701077. doi:10.1111/vsu.13847
Lavado RA, Lewis J, Montgomery JB. Continuous digital hypothermia for prevention and treatment of equine acute laminitis: A practical review. Vet J. 2023 Jul 26;300-302:106016. doi: 10.1016/j.tvjl.2023.106016. Epub ahead of print. PMID: 37507002.

APAVAC Immunotherapy

Clinical paper references

Patrick & Mathon, Didier & Simonet, Michel & Trouillet, Jean &
Valerie, Mathon & Rouquet, Nicole. (2020). TREATMENT OF CANINE OSTEOSARCOMA


Marconato L, Stefanello D, Sabattini S, Comazzi
S, Riondato F, Laganga P, Frayssinet P, Pizzoni S, Rouquet N, Aresu L. Enhanced
therapeutic effect of APAVAC immunotherapy in combination with dose-intense
chemotherapy in dogs with advanced indolent B-cell lymphoma. Vaccine. 2015 Sep
22;33(39):5080-6. doi: 10.1016/j.vaccine.2015.08.017. Epub 2015 Aug 18. PMID: 26296495.


Dias JNR, André AS, Aguiar SI, Gil S, Tavares
L, Aires-da-Silva F. Immunotherapeutic Strategies for Canine Lymphoma: Changing
the Odds Against Non-Hodgkin Lymphoma. Front Vet Sci. 2021 Aug 26;8:621758.
doi: 10.3389/fvets.2021.621758. PMID: 34513964; PMCID: PMC8427286.


Marconato L, Aresu L, Stefanello D, Comazzi S,
Martini V, Ferrari R, Riondato F, Rouquet N, Frayssinet P, Sabattini S.
Opportunities and challenges of active immunotherapy in dogs with B-cell
lymphoma: a 5-year experience in two veterinary oncology centers. J Immunother
Cancer. 2019 Jun 7;7(1):146. doi: 10.1186/s40425-019-0624-y. PMID: 31174615;
PMCID: PMC6554898.


Simonet M, Rouquet N and Frayssinet P (2013) Hydroxylapatite
(HA) Powder for Autovaccination Against Canine Non Hodgkin’s Lymphoma. Advances
in Biomaterials Science and Biomedical Applications. InTech. DOI:


Marconato L, Frayssinet P, Rouquet N, Comazzi
S, Leone VF, Laganga P, Rossi F, Vignoli M, Pezzoli L, Aresu L. Randomized,
placebo-controlled, double-blinded chemoimmunotherapy clinical trial in a pet
dog model of diffuse large B-cell lymphoma. Clin Cancer Res. 2014 Feb
1;20(3):668-77. doi: 10.1158/1078-0432.CCR-13-2283. Epub 2013 Dec 3. PMID:

Thiéry E, Marano I, Cadiergues MC, Semin MO, Sayag D, Raymond I, Lallemand E, Prise en charge multimodale d’un carcinome épidermoïde multicentrique incluant l’immunothérapie, Pratique Vétérinaire Equine, mars 2022, N°0213.

Simonet P, Mastocytomes canins et immunothérapie autologue, Cas cliniques, Vetofocus, 12/ 2017

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