Vetlig

Clinical Papers

Clinical References for all Vetlig Products

NOVALIG and NOVATEN synthetic implants

Hip

  • Buttin P, Crumière A and Goin B. A video guide to stabilization of canine hip luxation by intra-articular reconstruction of the round ligament using a synthetic implant. Am J Vet Res 2026: 1-2. DOI: 10.2460/ajvr.26.03.0099. 
  • Letesson J, Goin B, Cachon T and Viguier E. Biomechanical analysis of an extra-articular stabilization using a synthetic implant for craniodorsal hip luxation repair in a feline cadaver model: preliminary results. Comput Methods Biomech Biomed Engin 2021; 24: S122-S124. DOI: 10.1080/10255842.2021.1978758. 
  • Buttin P, Vallefuoco R. Ultra-high molecular weight polyethylene implants for treatment of traumatic hip luxation in 7 dogs and 3 cats. Abstract presented at: 2025 American College of Veterinary Surgeons Surgery Summit; October 23–25, 2025; Seattle, WA. doi:10.1111/vsu.70004
  • Fournet A, Matres Lorenzo L, Crumière A, Goin B. Surgical management of craniodorsal coxofemoral luxation in three dogs and three cats using a new ultra-high molecular weight polyethene implant. Abstract presented at: 22nd European Society of Veterinary Orthopaedics and Traumatology Congress; October 5–7, 2023; Venice, Italy. doi:10.5281/zenodo.14924496
  • Letesson J, Goin B, Viguier E and Cachon T. Validation of a biomechanical testing protocol of craniodorsal hip luxation in feline cadavers and comparison of two ultra-high molecular weight polyethylene materials used for extra-articular hip stabilisation. J Feline Med Surg 2022; 24: e360-e369. DOI: 10.1177/1098612X221114851. 

Achilles

  • Bohin C, Reinsch G, Vedrine B, et al. Outcomes of 11 cats with Achilles tendon (AT) rupture repair treated with a synthetic ultra-high-molecular-weight polyethylene (UHMWPE). Veterinary Surgery 2026; n/a. DOI: 10.1111/vsu.70107. 
  • Reinsch G, Crumière A, Goin B and Boursier J-F. Use of a Custom-made Synthetic Internal Brace for the Repair of a Proximal Gastrocnemius Muscle Tear in a Dog. VCOT Open 2025; 08: e78-e84. DOI: 10.1055/a-2551-2780. 
  • Buttin P, Goin B, Crumière AJJ, et al. Ex-vivo biomechanical analysis of an original repair of canine calcaneal tendon rupture using a synthetic implant as mechanical support fixed by sutures in the proximal tendinous part and by an interference screw in the bone distal part. Open Vet J 2023; 13: 645-653. DOI: 10.5455/OVJ.2023.v13.i5.18.
  • Goin B, Buttin P, Cachon T and Viguier E. Biomechanical comparison of two suturing techniques during Achilles tendinoplasty in dogs: preliminary results. Comput Methods Biomech Biomed Engin 2020; 23: S128-S129. DOI: 10.1080/10255842.2020.1816299. 
  • Buttin P, Goin B, Giraud N, et al. Biomechanical analysis of an original repair of an achilles tendon rupture in dogs: preliminary results. Comput Methods Biomech Biomed Engin 2020; 23: S52-S54. DOI: 10.1080/10255842.2020.1812157. 
  • Morton MA, Thomson DG, Rayward RM, Jiménez-Peláez M, Whitelock RG. Repair of chronic rupture of the insertion of the gastrocnemius tendon in the dog using a polyethylene terephthalate implant. Early clinical experience and outcome. Vet Comp Orthop Traumatol. 2015;28(4):282-7. doi: 10.3415/VCOT-14-08-0133. Epub 2015 Mar 25. PMID: 25804524.

Stifle CCL

  • Ödman S, Martenne-Duplan A, Finck M, et al. Arthroscopic intra-articular cranial cruciate ligament reconstruction with a synthetic implant yields satisfactory midterm outcome in 15 large-breed dogs. Am J Vet Res 2025: 1-10. DOI: 10.2460/ajvr.25.07.0259. 
  • Ödman S, Martenne-Duplan A, Finck M, et al. Intra-Articular Surgical Reconstruction of a Canine Cranial Cruciate Ligament Using an Ultra-High-Molecular-Weight Polyethylene Ligament: Case Report with Six-Month Clinical Outcome. Vet Sci 2024; 11. DOI: 10.3390/vetsci11080334. 
  • Fauqueux F, Goin B, Agbalé M, et al. Intra-articular replacement of the caudal cruciate ligament using a UHMWPE ligament under arthroscopic guidance in a dog: A case report. Open Vet J 2023; 13: 948-954. DOI: 10.5455/OVJ.2023.v13.i7.15. 
  • Goin B, Massenzio M, Lafon Y, et al. Ex-vivo biomechanical quasi-static and cyclic loading tests of new implant fixation system for intra-articular cranial cruciate ligament repair in canine cadaver models. Multidisciplinary Biomechanics Journal 2025; 2: 365-367. DOI: 10.46298/mbj.16256. 
  • Goin B. Ligamentoplastie synthétique et traitement chirurgical de la rupture du ligament croisé crânial chez le chien : analyses de l’existant, développement et évaluations d’un nouveau système de stabilisation. Université Claude Bernard Lyon 1, 2023. 
  • Goin B, Buttin P, Lafon Y, et al. Biomechanical cyclic loading test of a synthetic ligament fixation system used for intra-articular stabilization of deficient canine stifles. Open Vet J 2022; 12: 341-350. DOI: 10.5455/OVJ.2022.v12.i3.6. 
  • Goin B, Morvan V, Buttin P, et al. Biomechanical comparison of two femoral fixation methods for synthetic cranial cruciate ligament reconstruction in canine cadavers. Comput Methods Biomech Biomed Engin 2021; 24: S127-S129. DOI: 10.1080/10255842.2021.1978758. 
  • Rafael P, Goin B, Buttin P, et al. Comparison of two methods of fixation with interference screw for cranial cruciate ligament reconstruction in canine cadaver model. Comput Methods Biomech Biomed Engin 2020; 23: S247-S249. DOI: 10.1080/10255842.2020.1812846. 
  • Goin B, Rafael P, Blanc Q, et al. Biomechanical analysis of a ligament fixation system for CCL reconstruction in a canine cadaver model. Comput Methods Biomech Biomed Engin 2019; 22: S109-S111. DOI: 10.1080/10255842.2020.1713499. 
  • Blanc Q, Goin B, Rafael P, et al. Effect of the number of interference screws for the fixation of an intra-articular cranial cruciate ligament prosthesis in dogs: Biomechanical study. Comput Methods Biomech Biomed Engin 2019; 22: S102-S104. DOI: 10.1080/10255842.2020.1713496.
  • Philippe Buttin, Rosario Vallefuoco, & Hélène Le Pommellet. (2022, September 21). Stabilization of multiple ligament-injured stiffle using an ultra-high molecular weight polyethylen (UHMWPE) ligament in one dog and three cats. 21th Congress of the European Society of Veterinary Orthopaedics and Traumatology (ESVOT), Nice. https://doi.org/10.5281/zenodo.7273740

Patellar

  • Knight JM, Kudnig ST, Shaw T and Ng J. Synthetic Patellar Ligament Prosthesis for Treatment of Patellar Fracture in a Dog. VCOT Open 2025; 08: e1-e5. DOI: 10.1055/a-2501-9478. 
  • Castelli A, Garcia M, Camilletti P, et al. Patellar ligament repair with ultra-high molecular weight polyethylene implant results in successful outcome in 9 dogs. J Am Vet Med Assoc 2025. 
  • Lamère R, Guillet M, Scotti S, et al. Ultrahigh-molecular-weight polyethylene implant improves biomechanical properties for patellar ligament repair in dogs: an ex vivo randomized study. Am J Vet Res 2025; 86: ajvr.25.03.0087. DOI: 10.2460/ajvr.25.03.0087.

Carpus

  • Dekerle B, de Gail P, Crumière A and Goin B. Synthetic Reconstruction of the Carpal Short Radial Collateral Ligament Following a Partial Sprain Injury in a Dog. VCOT Open 2025; 08: e125-e131. DOI: 10.1055/a-2637-6332. 

Tarsus

  • Buttin P, Santoro V, Agbalé M, et al. Long-term outcome following synthetical reconstruction of the medial collateral tarsal ligament in a dog. Open Vet J 2022; 12: 375-382. DOI: 10.5455/OVJ.2022.v12.i3.11. 

Triceps

  • Degand S, Crumière A, Goin B and Sarrau S. Challenging surgical management of a major triceps tendon avulsion in a 4.6 kg cat without external coaptation. JFMS Open Rep 2025; 11: 20551169251334255. DOI: 10.1177/20551169251334255. 
  • Etchart N, Estoueigt E, Crumière A, et al. Proximal Ulnar Reinsertion of the Triceps Brachii Tendon with a Synthetic Implant in a Dog with Nonreconstructible Olecranon Fracture. VCOT Open 2024; 07: e119-e126. DOI: 10.1055/s-0044-1795075. 

Shoulder

  • Letesson J, Crumière A and Goin B. Long-Term Clinical Outcome of Medial Shoulder Instability in a Dog Treated with Synthetic Implant, Cortical Button, and Interference Screw. VCOT Open 2024; 07: e59-e68. DOI: 10.1055/s-0044-1787563. 
  • Buttin P, Goin B, Cachon T and Viguier E. Repair of Tendon Disruption Using a Novel Synthetic Fiber Implant in Dogs and Cats: The Surgical Procedure and Three Case Reports. Vet Med Int 2020; 2020: 4146790. DOI: 10.1155/2020/4146790. 

Cryotherapy ICE AID machine

Equine

  • Jacobs, CC,  O’Neil, E,  Prange, T.  Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpusVeterinary Surgery.  202251(7 10701077. doi:10.1111/vsu.13847 
  • In vivo effects of cold therapy and bandaging on core temperatures of equine superficial and deep digital flexor tendons. Vet Surg. 2025 Apr;54(3):470-477. doi: 10.1111/vsu.14235. Epub 2025 Feb 25. PMID: 39996479.Barber FA.
  • A comparison of crushed ice and continuous flow cold therapy. Am J Knee Surg. 2000 Spring;13(2):97-101; discussion 102. PMID: 11281337.
  • Luethy D. Cryotherapy Techniques: Best Protocols to Support the Foot in Health and Disease. Vet Clin North Am Equine Pract. 2021 Dec;37(3):685-693. doi: 10.1016/j.cveq.2021.07.005. PMID: 34782099.
  • Quam V, Yardley J, Quam M, Paz C, Belknap J. Cryotherapy provides transient analgesia in an induced lameness model in horses. Can Vet J. 2021 Aug;62(8):834-838. PMID: 34341594; PMCID: PMC8281941.
  • Morgan J, Stefanovski D, Lenfest M, Chatterjee S, Orsini J. Novel dry cryotherapy system for cooling the equine digit. Vet Rec Open. 2018 Jan 7;5(1):e000244. doi: 10.1136/vetreco-2017-000244. PMID: 29344364; PMCID: PMC5761284.
  • Van Eps AW. Therapeutic hypothermia (cryotherapy) to prevent and treat acute laminitis. Vet Clin North Am Equine Pract. 2010 Apr;26(1):125-33. doi: 10.1016/j.cveq.2010.01.002. PMID: 20381741.
  • Orsini JA. The Big Picture in Better Understanding the Equine Foot. Vet Clin North Am Equine Pract. 2021 Dec;37(3):521-528. doi: 10.1016/j.cveq.2021.07.001. Epub 2021 Oct 19. PMID: 34674909.
  • Lavado RA, Lewis J, Montgomery JB. Continuous digital hypothermia for prevention and treatment of equine acute laminitis: A practical review. Vet J. 2023 Jul 26;300-302:106016. doi: 10.1016/j.tvjl.2023.106016. Epub ahead of print. PMID: 37507002

Small Animal and human references.

  • Von Freeden N, Duerr F, Fehr M, Diekmann C, Mandel C, Harms O. Comparison of two cold compression therapy protocols after tibial plateau leveling osteotomy in dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017 Aug 10;45(4):226-233. doi: 10.15654/TPK-170049. Epub 2017 Jul 26. PMID: 28745777.
  • Drygas, K. A., McClure, S. R., Goring, R. L., Pozzi, A., Robertson, S. A., & Wang, C. (2011). Effect of cold compression therapy on postoperative pain, swelling, range of motion, and lameness after tibial plateau leveling osteotomy in dogs. Journal of the American Veterinary Medical Association, 238(10), 1284-1291. Retrieved Jul 8, 2026, from https://doi.org/10.2460/javma.238.10.1284
  •   WI Baltzer (2020) Rehabilitation of companion animals following orthopaedic surgery, New Zealand Veterinary Journal, 68:3, 157-167, DOI: 10.1080/00480169.2020.1722271
  • Janas K, Millis D, Levine D, Keck M. Effects of Cryotherapy on Temperature Change in Caudal Thigh Muscles of Dogs. Vet Comp Orthop Traumatol. 2021 Jul;34(4):241-247. doi: 10.1055/s-0041-1723786. Epub 2021 Feb 25. PMID: 33634436.
  • Szabo SD, Levine D, Marcellin-Little DJ, Sidaway BK, Hofmeister E, Urtuzuastegui E. Cryotherapy Improves Limb Use But Delays Normothermia Early After Stifle Joint Surgery in Dogs. Front Vet Sci. 2020 Jul 3;7:381. doi: 1c0.3389/fvets.2020.00381. PMID: 32719817; PMCID: PMC7350525.Barber FA.
  • A comparison of crushed ice and continuous flow cold therapy. Am J Knee Surg. 2000 Spring;13(2):97-101; discussion 102. PMID: 11281337.
  •  Su EP, Perna M, Boettner F, Mayman DJ, Gerlinger T, Barsoum W, Randolph J, Lee G. A prospective, multi-center, randomised trial to evaluate the efficacy of a cryopneumatic device on total knee arthroplasty recovery. The Journal of Bone and Joint Surgery. 2012; 94-B, Supple A:153-6. https://www.ncbi.nlm.nih.gov/pubmed/23118406.
  • Wright, B., Kronen, P.W., Lascelles, D., Monteiro, B., Murrell, J.C., Robertson, S., Steagall, P.V.M. and Yamashita, K. (2020), Ice therapy: cool, current and complicated. J Small Anim Pract, 61: 267-271.McCarthy RD, Ordóñez HJ, Semevolos SA.
  •  Waterman B, Walker JJ, Swains C, Shortt M, Todd MS, Machen SM, Owens BD. The efficacy of combined cryotherapy compression compared with cryotherapy alone following anterior cruciate ligament reconstruction. The Journal of Knee Surgery. 2012; 25, (02):155-160. https://www.ncbi.nlm.nih.gov/pubmed/22928433.
  • Murgier J, Cassard X. Cryotherapy with dynamic intermittent compression for analgesia after anterior cruciate ligament reconstruction. Preliminary study. Orthopaedics & Traumatology: Surgery & Research. 2014; 100:309-312. https://www.ncbi.nlm.nih.gov/pubmed/24679367.
  •  Nabıyev VN, Ayhan S, Adhıkarı P, Cetın E, Palaoglu S, Acaroglu RE. Cryo-compression therapy after elective spinal surgery for pain management: a cross-sectional study with historical control. Neurospine. 2018; 15(4):348-352. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347345/pdf/ns-1836070-035.pdf.
  • Klaber I, Greeff E, O’Donnell J. Compressive cryotherapy is superior to cryotherapy alone in reducing pain after hip arthroscopy. Journal of Hip Preservation Surgery. 2019; 0(0):1-6. https://academic.oup.com/jhps/advance-article/doi/10.1093/jhps/hnz048/5610188.
  • Murgier J, Cailliez J, Wargny M, Chiron P, Cavaignac E, Laffosse JM. Cryotherapy with dynamic intermittent compression improves recovery from revision total knee arthroplasty. The Journal of Arthroplasty. 2017; 1-4. https://pubmed.ncbi.nlm.nih.gov/28465126.
  •  Leegwater NC, Willems JH, Brohet R, Nolte PA. Cryocompression therapy after elective arthroplasty of the hip. Hip International. 2012; 22 (05):527-533. https://www.ncbi.nlm.nih.gov/pubmed/2311207

APAVAC Immunotherapy

Clinical paper references

  • Frayssinet, Patrick & Mathon, Didier & Simonet, Michel & Trouillet, Jean &Valerie, Mathon & Rouquet, Nicole. (2020). TREATMENT OF CANINE OSTEOSARCOMA
    USING AUTOLOGOUS ACTIVE IMMUNOTHERAPY WITH OR WITHOUT SURGERY.10.22533/at.ed.54620071223. 
  • Marconato L, Stefanello D, Sabattini S, Comazzi S, Riondato F, Laganga P, Frayssinet P, Pizzoni S, Rouquet N, Aresu L. Enhancedtherapeutic effect of APAVAC immunotherapy in combination with dose-intense chemotherapy in dogs with advanced indolent B-cell lymphoma. Vaccine. 2015 Sep
    22;33(39):5080-6. doi: 10.1016/j.vaccine.2015.08.017. Epub 2015 Aug 18. PMID: 26296495.
  • Dias JNR, André AS, Aguiar SI, Gil S, Tavares L, Aires-da-Silva F. Immunotherapeutic Strategies for Canine Lymphoma: Changing
    the Odds Against Non-Hodgkin Lymphoma. Front Vet Sci. 2021 Aug 26;8:621758.doi: 10.3389/fvets.2021.621758. PMID: 34513964; PMCID: PMC8427286
  • Marconato L, Aresu L, Stefanello D, Comazzi S, Martini V, Ferrari R, Riondato F, Rouquet N, Frayssinet P, Sabattini S. Opportunities and challenges of active immunotherapy in dogs with B-cell lymphoma: a 5-year experience in two veterinary oncology centers. J Immunother Cancer. 2019 Jun 7;7(1):146. doi: 10.1186/s40425-019-0624-y. PMID: 31174615; PMCID: PMC6554898.
  • Simonet M, Rouquet N and Frayssinet P (2013) Hydroxylapatite (HA) Powder for Autovaccination Against Canine Non Hodgkin’s Lymphoma. Advances in Biomaterials Science and Biomedical Applications. InTech. DOI: 10.5772/55129.
  •  Marconato L, Frayssinet P, Rouquet N, Comazzi Se VF, Laganga P, Rossi F, Vignoli M, Pezzoli L, Aresu L. Randomized, placebo-controlled, double-blinded chemoimmunotherapy clinical trial in a pet dog model of diffuse large B-cell lymphoma. Clin Cancer Res. 2014 Feb 1;20(3):668-77. doi: 10.1158/1078-0432.CCR-13-2283. Epub 2013 Dec 3. PMID: 24300788.
  • Thiéry E, Marano I, Cadiergues MC, Semin MO, Sayag D, Raymond I, Lallemand E, Prise en charge multimodale d’un carcinome épidermoïde multicentrique incluant l’immunothérapie, Pratique Vétérinaire Equine, mars 2022, N°0213.
  • Simonet P, Mastocytomes canins et immunothérapie autologue, Cas cliniques, Vetofocus, 12/ 201
  • Rinaldi V, Bongiovanni L, Crisi PE, Vignoli M, Peli RE, Masci S, Boari A, Finotello R. APAVAC Immunotherapy for the Adjuvant Treatment of a Canine Mucosal Melanoma. Vet Sci. 2024 Dec 6;11(12):628. doi: 10.3390/vetsci11120628. PMID: 39728968; PMCID: PMC11680214

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