Soft Tissue Internal Fixation

Bio Materials

Synthetic : Reliable, predictable and reproducible results

100% synthetic, 100% sure, 45% bioactive elements.

GlassBONE™ belongs to the family of bioactive glasses, a synthetic and bioactive bone substitute. It is composed of mineral elements such as silicon, calcium, sodium and phosphorus. All of the mineral ions that make up GlassBONE™ are naturally present in the human body and are known to play physiologically crucial roles in the process of bone formation and mineralisation. This composition overcomes the risk of transmission of pathogens and provides optimum safety for patients and surgeons.

The 45% of silicon in the compound of GlassBONE™ ensures bioactivity in the process of natural bone regeneration.

It can be used for, filling TTA cages, spinal cages, spinal fusion, trauma, bone defects, dental and tibia osteotomy. It comes in granules or injectable putty. Granules you mix with blood, autologous bone or saline prior to use.

We can provide GlassBONE™ in different sizes and volumes :

Product Granulometry Volume
GlassBone granular 0.5-1mm 1cc
0.5-1mm 5cc
1-3mm 5cc
1-3mm 10cc
1-3mm 16cc

Product Volume
GlassBone putty 1cc



Does it show on x-rays?
You won’t see it like as clear as a Ti screw but it is visible, and if you x-ray 3/6 months post operatively you will see the bone ingrowth as the Glassbone resorbs.

How long does it take to resorb?
From approximately 6 months for the smallest size granules, the larger the size the longer it will take.

Can you mix it with antibiotics?
Yes you can and blood and bone chips from the patient, also sterile saline to mix the granules if no autologous blood is available. PRP has also shown to give good results.

Has it been used in animals?

Can it be load bearing?
no it is not, it is used for bone defects and to restore volume, it could not be used without implants to support the fracture or keep the fracture in place.

How long has this product been sold?
Since 2000 Glassbone started, it is CE marked and a class 3 device in the USA for human medicine.

Is Glassbone Osteo inductive?
yes and conductive and bio active.

The dissolution of Glassbone induces ion exchanges with biological fuids enabling the formation of a mineral layer, direct biological binding between the biomaterial and the bone. This mineral layer prevents any micro movements of granules in the bone defect, which would impede osteo integration.

Osteo integration of the biomaterial provides stabilisation of the bone defect in respect of the anatomical alignment and reduces the migration of the product.

How does it work?
It is bioactive due to the minerals it is made from, these in turn bind to the bone it is placed next to. It is also osteo stimulating.

The ability to osteo stimulate increases the vascularisation of the bone defect and the recruitment of osteoblasts to promote bone regeneration.

The release of silicium ions makes it possible to genetically stimulate the recruitment and proliferation of stem cells, and the differentiation and proliferation of osteoblasts in the defect with a view to full natural bone remodelling.

The intrinsic properties of bioactive glass give it the ability to promote the natural bone regeneration process by releasing mineral ions.



  1. 1. Hench, L.L. The story of Bioglass. J Matter Sci: Matter Med. Springer Science, 2006, Vol. 17, pp. 967- 978.
  2. Xynos, I.D. and al. Bioglass 45S5 stimulates osteoblasts turnover and enhances bone formation in vitro: implications and applications for bone tissue engineering. Calcif Tissue Int. Springer, 2000, Vol. 67, pp. 321-9.
  3. Jell, G. and al. Gene activation by bioactive glasses. J Mater Sci: Mater Med. Springer Science, 2006, Vol. 17, pp. 997-1002.
  4. Tsigkou, O. and al. Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements. Biomaterials. Elsevier, 2009, Vol. 30, pp. 3542-50.
  5. Oonishi, H. and al. Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass ceramic and hydroxyapatite. J Biomed Mater Res. John Wiley & Sons, Inc., 2000, Vol. 51.
  6. Jones, J.R. Review of bioactive glass: from Hench to hybrids. Acta Biomaterialia. Elsevier, 2013, Vol. 9, pp. 4457-4486.
  7. Allan, I., Newman, H. and Wilson, M. Antibacterial activity of particulate Bioglass against supra- and subgingival bacteria. Biomaterials. Elsevier, 2001, Vol. 22, pp. 1683-1687.
  8. Eberhard, J. and al. The effect of the topical administration of bioactive glass on in ammatory markers of human experimental gingivitis. Biomaterials. Elsevier, 2005, Vol. 26, pp. 1545-51.
  9. Ameri E., and al. Bioactive Glass versus Autogenous Iliac Crest Bone Graft in Adolescent Idiopathic Scoliosis Surgery. Acta Medica Iranica 2009; 47(1): 41-45.
  10. Illarreborde B., and al. Bioactive Glass as a bone substitute for spinal fusion in adolescent idiopathic scoliosis. J Pediatr Orthop 2008;28:347-351.
  11. Shapoff C, and al. Evaluation of Bioactive Glass as a bone graft extender in sinus elevation surgeries. International Journal of Oral Implant and clinical results 2010;1:33:155-162
  12. Bone Augmentation Using Bioglass® Particulates in Dogs: Pilot Study. In Yamamuro, T., Kokubo, T., Nakamura, T. (eds). Bioceramics 5. Kyoto, Kobonshi Kankokai 139-146. Wilson, J. and al. Kyoto: s.n., 1992.